Resveratrol Protects Against Atherosclerosis

Resveratrol, a phytopolyphenol compound found abundantly in red wine, protects against atherosclerosis by multiple mechanisms. Atherosclerosis develops from an excess of low-density lipoprotein (LDL) in the arteries, oxidative stress, inflammation and endothelial cell injury and dysfunction; the process leads to the formation of fibrous plaques that may rupture.

Several activities of resveratrol help inhibit the progression of atherosclerosis. Studies show that the compound regulates the production of both vasoconstricting and vasodilating substances, inhibits oxidative stress and the generation of reactive oxygen species, inhibits inflammation, prevents the oxidation and uptake. of LDL, suppresses platelet aggregation at plaque sites, and decreases the accumulation of smooth muscle cells in the blood vessels.

These findings support previous data on the wide-ranging benefits of resveratrol, including protection against cancer and neurodegenerative diseases and suggest its future role in the prevention of cardiovascular disease.

-Laura J. Ninger, ELS

Fan E, Zhang L, Jiang S, Bai Y. Beneficial effects of resveratrol on atherosclerosis. J Med Food. 2008 Dec;11(4):610-4.